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目的了解杭州市下城区2011年-2012年手足口病(HFMD)的流行病学特征,及时掌握疫情趋势,为制定预防控制措施提供实验依据。方法采用实时荧光定量PCR方法对手足口病患者标本进行肠道病毒(EV)、肠道病毒71型(EV71)和柯萨奇病毒16型(CoxA16)特异性核酸的检测。结果 121例HFMD患者标本中,EV71阳性率21.49%(26例);Cox A16阳性率6.61%(8例);其他肠道病毒阳性率14.88%(18例);2岁~4岁儿童感染占所有感染者的90.38%;男女儿童间肠道病毒感染无明显差异。结论该地区的手足口病防控形势仍然严峻,应继续加强监测。
Objective To understand the epidemiological characteristics of hand-foot-mouth disease (HFMD) in the lower city of Hangzhou from 2011 to 2012, grasp the epidemic trend in time and provide experimental evidence for the development of prevention and control measures. Methods Real-time fluorescence quantitative PCR was used to detect EV71, CoxA16 and CoxA16 in hand, foot and mouth disease patients. Results The positive rate of EV71 was 21.49% (26 cases) in 121 cases of HFMD. The positive rate of Cox A16 was 6.61% (8 cases). The positive rate of other enteroviruses was 14.88% (18 cases). The infection rate of children aged 2 to 4 years 90.38% of all infected persons; there was no significant difference in enterovirus infection between boys and girls. Conclusion The hand-foot-mouth disease prevention and control in this area is still grim, and monitoring should continue to be strengthened.