丙型肝炎病毒(HC)是肠道外非甲非乙肝炎的主要病原,也是引起输血后肝炎的主要致病因子,1989年由Choo首次发现。HCV具高度异质性,Simmonds据此将其分为不同的型及亚型,目前已确定了6种基因型及100多种亚型。HCV基因组为(+)ssRNA,全长约有9500个核苷酸,基因组结构与黄病毒及瘟病毒属病毒相似。HCV只有一个开放阅读框,包括3个结构蛋白:核心蛋白(C)及胞膜糖蛋白E1、E2。有报道认为 Hepatitis C virus (HC) is the major causal agent of extra-intestinal non-A, non-B hepatitis, and is also the major causative agent of post-transfusion hepatitis, first discovered by Choo in 1989. HCV is highly heterogeneous, Simmonds accordingly divided into different types and subtypes, has identified six genotypes and more than 100 subtypes. The HCV genome is (+) ssRNA, with a total length of about 9500 nucleotides. The genome structure is similar to the flavivirus and the pestivirus. HCV has only one open reading frame, including three structural proteins: core protein (C) and the membrane glycoproteins E1, E2. There are reports that