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目的观察抗α1肾上腺素受体抗体(简称α1受体抗体)对高血压患者心室重构的影响。方法采用酶联免疫吸附法(ELISA)对553例高血压患者进行血清抗α1受体抗体检测并记录所有患者的超声心动图检查结果。运用多元logistic回归分析高血压患者左心室扩大的影响因素。结果553例高血压患者血清抗α1受体抗体阳性率为32．3％(179／553)。抗α1受体抗体阳性组中左心房扩大占的比例明显高于阴性组(分别为53．6％,44．3％,P<0．05);阳性组中左心室扩大所占比例也明显高于阴性组(分别为12．8％,6．1％,P<0．01)。多元logistic回归共筛选出4个左心室扩大的危险因素:男性、病程、心率、血清抗α1受体抗体(P均<0．05)。结论抗α1受体抗体与高血压患者左心室扩大有关,该抗体阳性可能对预测高血压患者左心室重构具有重要意义。
Objective To observe the effect of anti-α1 adrenergic receptor antibody (α1 receptor antibody) on ventricular remodeling in patients with essential hypertension. Methods Serum anti-α1 antibody was detected by enzyme-linked immunosorbent assay (ELISA) in 553 hypertensive patients and the echocardiographic results of all patients were recorded. Multivariate Logistic Regression Analysis of Factors Affecting Left Ventricular Enlargement in Hypertensive Patients. Results The positive rate of serum anti-α1 antibody in 553 hypertensive patients was 32.3% (179/553). The ratio of left atrium enlargement in the anti-α1 antibody positive group was significantly higher than that in the negative group (53.6% and 44.3%, respectively; P <0.05), and the proportion of left ventricular enlargement in the positive group was also significant Higher than the negative group (12.8% and 6.1% respectively, P <0.01). Multivariate logistic regression was used to screen 4 risk factors of left ventricular enlargement: male, duration of disease, heart rate and serum anti-α1 antibody (all P <0.05). Conclusion The anti-α1 antibody is associated with the enlargement of left ventricle in hypertensive patients. The positive of this antibody might be of significance for the prediction of left ventricular remodeling in hypertensive patients.