一例25岁的镰状血球贫血症妇女,入院23天后因严重感染发展为败血症。在连续应用妥布拉霉素治疗的31天内,常规监测药物的血峰、谷浓度。第50天患者发展为腕足痉挛,血钙1.19mmol/L(正常2.20～2.65)、血蛋白17g/L、血钾2.2mmol/L、血肌酐42μmol/L。尽管静脉输注葡萄糖酸钙(每6小 A 25-year-old woman with sickle cell anemia developed sepsis 23 days after admission due to a serious infection. During the 31 days following the continuous administration of tobramycin, the blood pressure and trough concentration of the drug were routinely monitored. On the 50th day, the patients developed brachiopathia, calcium 1.19mmol / L (normal 2.20 ~ 2.65), blood protein 17g / L, serum potassium 2.2mmol / L, serum creatinine 42μmol / L. Although intravenous infusion of calcium gluconate (every 6 hours