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目的：通过Ｓ１８０在昆明种小鼠活体生长，探讨自体脾移植对肿瘤免疫的影响。方法：建立动物模型后两个月，皮下接种Ｓ１８０，观察荷瘤小鼠的肿瘤生长、自然生存期及检测ＮＫ细胞活性，研究自体脾移植的抗肿瘤作用。结果：约占原脾脏１／３量的自体脾移植组显示了较强的抗肿瘤作用，该组同脾切除组相比可见肿瘤生长慢，ＮＫ细胞活性高，小鼠生存期长。结论：自体脾移植不但具有抗感染作用，也具有不可忽视的抗肿瘤及肿瘤免疫监视功能。严重脾外伤时，脾自体移植术不失为一种行之有效的保脾手术。
OBJECTIVE: To investigate the effect of autologous splenic transplantation on tumor immunity by growing S180 mice in vivo in Kunming. METHODS: Two months after the animal model was established, S180 was inoculated subcutaneously to observe the tumor growth and natural survival of the tumor-bearing mice and to detect the activity of NK cells. The anti-tumor effect of autologous spleen transplantation was studied. RESULTS: Autologous splenic autotransplantation group which accounted for about 1/3 of the original spleen showed strong anti-tumor effect. Compared with splenectomy group, this group showed slower tumor growth, higher NK cell activity, and longer mouse survival time. Conclusion: Autologous spleen transplantation not only has anti-infective effect, but also can not ignore the anti-tumor and tumor immune surveillance. Severe spleen trauma, splenic autotransplantation is an effective spleen protection surgery.