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目的探讨影响幽门螺杆菌(Helicobacter pylori,Hp)根除效果的相关因素,为临床采取干预措施提高根除率提供依据。方法经~(14)C-尿素呼气试验确诊为Hp阳性,且经胃镜检查确诊为慢性胃炎和消化性溃疡的647例患者,以12日艾普拉唑联合胶体果胶铋、阿莫西林、左氧氟沙星的四联疗法作为初次根除治疗方案,根据Hp根除结果分为根除成功组及根除失败组,采用单因素分析及二分类Logistic回归进行统计分析,分析不同因素对Hp根除率的影响。结果四联方案Hp根除率为89.5%。单因素分析发现:吸烟及依从性与Hp根除率有关,差异有统计学意义(P<0.05)。二分类Logistic回归分析发现:患者吸烟、依从性是影响Hp根除率的主要因素(P<0.05)。结论吸烟及依从性是影响Hp根除率的不利因素,可采取相应干预措施提高Hp根除率。
Objective To investigate the related factors affecting the eradication effect of Helicobacter pylori (Hp) and provide the basis for improving the eradication rate in clinical practice. Methods 647 patients diagnosed as chronic gastritis and peptic ulcer by gastroscopy were diagnosed as Hp positive by ~ (14) C-urea breath test. The patients were treated with ioprazole combined with colloidal bismuth pectin, amoxicillin , Levofloxacin quadruple therapy as the initial eradication treatment program, according to the results of Hp eradication were divided into successful and eradication groups, single-factor analysis and binary logistic regression analysis of the impact of different factors on the Hp eradication rate. Results quadruple protocol Hp eradication rate was 89.5%. Univariate analysis found that smoking and compliance were related to Hp eradication rate, the difference was statistically significant (P <0.05). Binary Logistic regression analysis found that smoking and compliance were the main factors affecting the eradication rate of Hp (P <0.05). Conclusion Smoking and compliance are the negative factors that affect the eradication rate of Hp. Corresponding intervention measures can be taken to improve the eradication rate of Hp.