论文部分内容阅读
目的:探讨缺血性脑卒中患者经卡托普利治疗前后血浆氧化低密度脂蛋白(oxLDL)和一氧化氮(NO)水平的变化及其意义。方法:测定45例急性缺血性脑卒中患者、30名健康体检者血浆oxLDL、NO水平及患者服用卡托普利一个月、三个月后血浆oxLDL、NO水平。结果:卒中组oxLDL明显高于对照组(P<0.01),NO明显低于对照组(P<0.01);卒中组服用卡托普利一个月及三个月后oxLDL。均比服药前明显降低(P<0.01),而NO明显增高(P<0.01)。结论:脑卒中患者LDL对氧化修饰的易感性增加,氧化修饰的LDL可通过灭活NO,激活血小板而促进动脉硬化,易致血栓形成。卡托普利具有抗氧化作用,可降低脑卒中患者血浆oxLDL,改善内皮功能,提升NO水平,对脑卒中防止有重要作用。
Objective: To investigate the changes of plasma oxLDL and NO levels in patients with ischemic stroke before and after treatment with captopril. Methods: Plasma oxLDL and NO levels were measured in 45 patients with acute ischemic stroke and 30 healthy subjects and plasma oxLDL and NO levels after taking captopril for one month and three months. Results: The oxLDL level in stroke group was significantly higher than that in control group (P <0.01), NO was significantly lower than that in control group (P <0.01). OxLDL in captopril group was lower than that in control group at one month and three months. Were significantly lower than before treatment (P <0.01), while NO was significantly increased (P <0.01). Conclusion: The susceptibility of LDL to oxidative modification is increased in patients with stroke. Oxidatively modified LDL can promote atherosclerosis and thrombosis by inactivating NO and activating platelets. Captopril has anti-oxidant effects, can reduce plasma oxLDL in stroke patients, improve endothelial function and increase NO levels, which play an important role in preventing stroke.