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目的 :比较自体外周血干细胞联合自体骨髓移植 (APBSCT +ABMT)与单纯自体骨髓移植 (ABMT)后造血功能重建及有关临床指标。方法 :以 10例APBSCT +ABMT及 10例ABMT病人作为研究对象。结果 :移植后APBSCT +ABMT组与ABMT组白细胞 >1.0× 10 9·L 1、中性粒细胞 >0 .5× 10 9·L 1和血小板 >5 0× 10 9·L 1的中位数时间分别为 10、11、13d和 15、17、2 0d(均为P <0 .0 5 )。输血浆量及血小板量APBSCT +ABMT组明显较ABMT组为少 (P <0 .0 1)。伊米配能使用率ABMT组明显高于APBSCT+ABMT组 (P <0 .0 1)。出血发生率及程度两组均有显著差异 (P <0 .0 5 )。住层流病房时间APBSCT +ABMT组明显较ABMT组短 (P <0 .0 1)。但血红蛋白下降程度两组无显著差异 (P >0 .0 5 )。结论 :APBSCT +ABMT可加快造血功能重建速度 ,并降低严重感染和出血的发生率 ,减少血液成分输注及抗生素的使用 ,缩短住院时间 ,同时可利用骨髓进行体外净化 ,因此仍不失为一种治疗恶性肿瘤的有效手段。
OBJECTIVE: To compare the hematopoietic reconstitution with peripheral blood stem cells autologous bone marrow transplantation (APBSCT + ABMT) and simple autologous bone marrow transplantation (ABMT) and related clinical parameters. Methods: Ten cases of APBSCT + ABMT and 10 cases of ABMT were studied. Results: The median number of white blood cells> 1.0 × 10 9 · L 1, neutrophil> 0.5 × 10 9 · L 1 and platelets> 5 0 × 10 9 · L 1 in APBSCT + ABMT group and ABMT group after transplantation The time was 10, 11, 13d and 15, 17, 20d respectively (all P <0.05). The volume of blood transfusion and platelet volume in APBSCT + ABMT group were significantly less than those in ABMT group (P <0.01). The utilization rate of imipenem in ABMT group was significantly higher than that in APBSCT + ABMT group (P <0.01). The incidence and extent of bleeding were significantly different between the two groups (P <0.05). The stratified ward time in APBSCT + ABMT group was significantly shorter than that in ABMT group (P <0.01). However, there was no significant difference in hemoglobin decline between the two groups (P> 0.05). Conclusion: APBSCT + ABMT can accelerate the speed of hematopoietic reconstitution, reduce the incidence of severe infection and bleeding, reduce the infusion of blood components and the use of antibiotics, and shorten the length of hospital stay. Meanwhile, bone marrow can be used for in vitro purification, so it is still a kind of treatment Effective means of malignancy.