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目的 应用血栓弹力图 (TEG) ,探讨肺癌患者体内凝血状态。方法 对 30例肺癌患者于治疗前进行TEG及常规凝血象的测定 ,另选 10 0例健康人为对照组。结果 绝大多数 (2 9 30 )肺癌患者TEG表现为高凝图象 :γ值 4 4 4± 1 80、K值 2 0 6± 1 73较正常对照组明显缩短 ,Ma值6 6 4 4± 6 4 5、Mε值 2 0 9 79± 6 6 0 7较正常对照组明显增宽 (P <0 0 1)随着病情发展 ,γ、K值缩短及Ma、Mε值增宽更明显。结论 肺癌患者体内存在病理性高凝状态 ,临床可根据TEG的变化诊断肺癌患者凝血状态 ,对判断病情、预后及指导治疗具有参考价值
Objective To investigate the coagulation status in patients with lung cancer using thromboelastography (TEG). Methods Thirty lung cancer patients were tested for TEG and routine coagulation before treatment. Another 100 healthy people were selected as the control group. Results The vast majority of (2 930) lung cancer patients showed hypercoagulative images of TEG: γ value of 4 4 4 ± 1 80, K value of 20 6 ± 1 73 was significantly shorter than that of normal control group, Ma value of 6 6 4 4 ± 584.The Mε value of 2 0 9 79± 6 6 7 was significantly wider than that of the normal control group (P < 0 01). With the development of the disease, the γ and K values were shortened and the Ma and M ε values were more widened. Conclusion Pathological hypercoagulability exists in patients with lung cancer. Clinically, the coagulation status of lung cancer patients can be diagnosed according to the changes of TEG, which has a reference value in judging the condition, prognosis and guiding treatment.