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目的:研究给予外源性Apelin-13治疗对血流动力学、血浆血管紧张素Ⅱ(Angiotensin-Ⅱ,AngⅡ)和肾上腺髓质素(Adrenomedulin,ADM)水平的影响。方法:将50只大鼠随机分为3组:心衰组(n=20)、治疗组(n=20)和正常对照组(n=10),阿霉素(ADR)腹腔注射建立大鼠心衰模型,治疗组给药外源性Apelin-13治疗,检测大鼠血浆AngⅡ和ADM水平(ELISA法)以及血流动力学的水平。结果:心衰组和治疗组血浆AngⅡ和ADM水平比正常对照组增高,但治疗组血浆AngⅡ和ADM水平比心衰组明显降低,治疗组左心室内压最大升降速度(LV±dp/dtmax)、左室最大收缩压(LVESP)比心衰组增高,左室舒张末期压(LVEDP)比心衰组低(P均<0.05)。结论:外源性apelin-13抑制体内的AngⅡ和ADM水平可能对ADR诱导的大鼠心衰有保护作用。
Objective: To investigate the effects of exogenous Apelin-13 on hemodynamics, Angiotensin-Ⅱ (AngⅡ) and Adrenomedulin (ADM) levels. Methods: Fifty rats were randomly divided into three groups: heart failure group (n = 20), treatment group (n = 20) and normal control group (n = 10) Heart failure model, exogenous Apelin-13 treatment in the treatment group, plasma levels of AngⅡ and ADM (ELISA method) and hemodynamics in the rats. Results: The levels of Ang Ⅱ and ADM in heart failure group and treatment group were higher than those in normal control group, but the levels of Ang Ⅱ and ADM in treatment group were significantly lower than those in heart failure group. The maximal velocity of left ventricular pressure (LV ± dp / dtmax) (LVESP) was higher than that of heart failure group, and left ventricular end-diastolic pressure (LVEDP) was lower than that of heart failure group (all P <0.05). Conclusion: Exogenous apelin-13 inhibits AngⅡ and ADM levels in vivo may have protective effects on ADR-induced heart failure in rats.