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目的：研究水溶性高聚物聚乙烯吡咯烷酮（ＰＶＰ）和聚乙二醇（ＰＥＧ）对药物与β环糊精（βＣＤ）包合作用的影响。方法：用相溶解度法研究了药物在βＣＤ溶液中或同时含有βＣＤ和高聚物的溶液中的热力学性质。结果：在βＣＤ溶液中水溶性高聚物的最佳浓度区域为１５～３０ｇ·Ｌ－１。低浓度ＰＶＰ或ＰＥＧ对βＣＤ溶液的粘度没有显著影响；２５ｇ·Ｌ－１ＰＥＧ的加入使βＣＤ对氯霉素的增溶效率增加了１５％，而２５ｇ·Ｌ－１ＰＶＰ则使βＣＤ对核黄素的增溶效率增加了９８％。说明水溶性高聚物可以增强βＣＤ对药物的增溶效率；在包合介质中加入高聚物使得包合反应的ΔＨ负值增大，同时ΔＳ负值也增大，说明焓效应是包合作用的原动力。结论：水溶性高聚物可以增加药物与βＣＤ的包合作用。
Objective: To study the effect of water-soluble polymer polyvinylpyrrolidone (PVP) and polyethylene glycol (PEG) on the inclusion of drug and β-cyclodextrin (βCD). Methods: The phase-solubility method was used to study the thermodynamic properties of the drug solution in β-CD solution or both β-CD and polymer solution. Results: The optimal concentration of water-soluble polymer in βCD solution was 15 ~ 30g · L-1. Low concentrations of PVP or PEG had no significant effect on the viscosity of β-CD solution; addition of 25g · L-1PEG increased the efficiency of solubilization of chloramphenicol by βCD by 15%, while that of 25g · L-1PVP Then β CD to riboflavin solubilization efficiency increased by 98%. Indicating that the water-soluble polymer can enhance the efficiency of β CD solubilization of drugs; inclusion compound in the inclusion of the polymer so that the ΔH negative inclusion reaction increases, while the negative ΔS also increased, indicating that the enthalpy effect is Co-integration of the driving force. Conclusion: Water-soluble polymers can increase the inclusion of drugs and β CD.