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目的了解支原体对妇女泌尿生殖道的致病情况,并监测其耐药性变迁,以指导临床合理用药。方法对1220例妇科炎症患者和183例无症状者按标准操作收集其阴道穹窿部白带标本,立即进行解脲支原体(Uu)和人型支原体(Mh)的检测并监测其对9种抗菌药物的耐药性。结果支原体在妇科炎症患者中的检出率为70.9%,高于无症状者的22.4%,差异有统计学意义(P<0.05);单纯Uu对环丙沙星、氧氟沙星等奎诺酮类药物高度耐药,对其他7种药物耐药性均低于10%,Uu+Mh混合感染者对奎诺酮类和大环内酯类都有较高耐药性,仅对原始霉素、交沙霉素、强力霉素、红霉素较敏感,耐药率低于10%。结论妇科炎症患者进行泌尿生殖道支原体的检测对临床诊断和合理使用抗生素具有重要意义。
Objective To understand the pathogenicity of mycoplasma to the genitourinary tract of women and to monitor the change of drug resistance so as to guide clinical rational drug use. Methods 1220 cases of gynecological inflammation and 183 cases of asymptomatic patients were collected according to standard vaginal fornix vaginal tape specimens, and immediately for Uu and Mycoplasma hominis (Mh) detection and monitoring of 9 kinds of antibacterial drugs Resistance. Results The detection rate of mycoplasma in patients with gynecological inflammation was 70.9%, which was higher than that of asymptomatic patients (22.4%) (P <0.05). Uu had no effect on cinnamon such as ciprofloxacin and ofloxacin Ketones were highly resistant and resistant to the other seven drugs at less than 10%. Uu + Mh mixed patients had higher resistance to both quinolones and macrolides, Su, josamycin, doxycycline, erythromycin more sensitive rate of less than 10%. Conclusion Gynecological inflammation in patients with genitourinary tract mycoplasma detection of clinical diagnosis and rational use of antibiotics is of great significance.