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目的探讨染色体多态性与男性不育的关系。方法对297例临床诊断为少精子症、无精子症的男性不育患者按常规技术方法制备外周血染色体,并对染色体核型进行分析。结果 297例患者中有68例染色体核型异常,异常检出率为22.90%。其中,多态性变异12例,占异常核型的17.65%,包括次缢痕增长3例,9号染色体倒位2例,D/G组随体变异1例,Y染色体变异6例。结论染色体多态性与男性不育存在明显关系,不能忽视其临床效应。
Objective To explore the relationship between chromosomal polymorphism and male infertility. Methods A total of 297 male infertile patients with oligozoospermia and azoospermia were enrolled in this study. Chromosomes of peripheral blood were prepared by routine techniques and their karyotypes were analyzed. Results Of the 297 patients, 68 were abnormal in karyotype, with an abnormality of 22.90%. Among them, 12 cases of polymorphic variation accounted for 17.65% of the abnormal karyotype, including 3 cases of secondary scar growth, 2 cases of inverted chromosome 9, 1 case of D / G group and 6 cases of Y chromosome. Conclusion There is a clear relationship between chromosome polymorphism and male infertility, and its clinical effect can not be ignored.