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用丝线缝扎大鼠前牙颈部形成实验性牙周炎的同时,分别用消炎痛和固齿膏治疗以抑制炎症的形成,以盐水作对照,结果发现在治疗的第7d和21d,固齿膏和消炎痛组与盐水对照组和未用药的牙周炎对照组相比,牙龈指数(GI)和牙周袋深(PD)明显降低,炎细胞浸润和骨吸收减少。与未缝扎的正常对照组无显著差异。提示固齿膏和消炎痛对实验性牙周炎都有一定的抑制作用。
While the experimental periodontitis was formed by ligating the anterior teeth neck of rats with silk suture, the formation of inflammation was inhibited by indomethacin and solid toothpaste respectively, and saline was used as control. The results showed that on the 7th and 21st day of treatment, The gingival index (GI) and periodontal pocket depth (PD) were significantly lower in the toothpaste and indomethacin groups than in the saline control group and the untreated periodontitis control group, with decreased inflammatory cell infiltration and bone resorption. There was no significant difference with the normal control group without suture. Tip solid toothpaste and indomethacin on experimental periodontitis have a certain inhibitory effect.