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为探讨内皮素(ET)在肝坏死中的发病学意义,作者在四氯化碳(CCl_4)肝坏死模型上观察免疫活性内皮素(ET-ir)变化及其ET抗血清(ET-Ab)的治疗作用。结果发现,肝坏死大鼠血浆ET-ir含量(17.7±2.6 ng/L)显著高于对照组 9.5±1.6 ng/L(P<0.05),用特异的 ET-Ab 治疗可明显降低 ET水平,减轻肝细胞内钙超载的程度,减少肝组织脂质过氧化形成,使血浆丙氨酸转氨酶和乳酶脱氢酶活性下降。结果表明,ET-Ab
To investigate the pathogenetic significance of endothelin (ET) in hepatic necrosis, the authors observed changes in immunoreactive endothelin (ET-ir) and ET antiserum (ET-Ab) on carbon tetrachloride (CCl_4) hepatic necrosis model. Therapeutic effect. The results showed that the plasma ET-ir content in hepatic necrosis rats (17.7±2.6 ng/L) was significantly higher than that in the control group (9.5±1.6 ng/L) (P<0.05), and treatment with specific ET-Abs significantly reduced the ET levels. Reduce the extent of intracellular calcium overload in liver cells, reduce the formation of lipid peroxidation in liver tissue, and decrease the activity of plasma alanine aminotransferase and lactase dehydrogenase. The results show that ET-Ab