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目的探讨胃腺癌中微淋巴管的分布特点及其与淋巴结转移的关系。方法采用微淋巴管特异标记D2-40对60例胃腺癌的癌中心组织、癌边缘区组织及其相应正常组织进行免疫组织化学染色检测微淋巴管密度,以CD34标记血管作对比。结果胃癌中心未见明显微淋巴管;边缘区微淋巴管明显增多,胃癌边缘区淋巴管密度较正常胃组织增高(P<0.01),胃癌边缘区微淋巴管密度与胃腺癌分化程度与淋巴结转移有关(P<0.05或0.01)。结论胃癌组织边缘区存在新生微淋巴管,癌周围微淋巴管密度增加与胃腺癌分化程度及淋巴结转移有关,胃癌边缘区微淋巴管密度测定对淋巴结转移可能性的判断具有一定意义。
Objective To investigate the distribution of lymphatic vessels in gastric adenocarcinoma and its relationship with lymph node metastasis. Methods The lymphatic vessel specific marker D2-40 was used to detect the lymphatic vessel density in 60 cases of gastric adenocarcinoma of the cancer center, marginal zone of cancer and its corresponding normal tissues. CD34-labeled blood vessels were used for comparison. Results There were no obvious lymphatic vessels in the gastric cancer center. The number of lymphatic vessels in the marginal zone was significantly increased, and the lymphatic vessel density in the marginal zone of gastric cancer was higher than that in the normal gastric tissues (P <0.01). The lymphatic vessel density in the marginal zone of gastric cancer was positively correlated with lymph node metastasis Related (P <0.05 or 0.01). Conclusion There is a neoplasm of lymphatic vessels in the marginal zone of gastric cancer. The increased lymphatic vessel density around the neoplasm is related to the differentiation and lymph node metastasis of gastric adenocarcinoma. The determination of lymphatic vessel density in the marginal zone of gastric carcinoma has some significance for the possibility of lymph node metastasis.