目的探讨甲醛对小鼠体细胞染色体端粒的损伤。方法对昆明小鼠灌胃不同剂量的甲醛(10、20、40 mg/kg)连续7 d,通过PCR方法检测小鼠血细胞、肝细胞、肾细胞染色体端粒DNA重复序列的相对长度(OD260)。结果与对照组比较,10、20和40 mg/kg组小鼠的血细胞、肝细胞和肾细胞染色体端粒DNA重复序列缩短,差异有统计学意义(P<0.05,P<0.01),且随着甲醛染毒剂量的升高呈缩短趋势。结论甲醛暴露能破坏小鼠染色体端粒的稳定。 Objective To investigate the effect of formaldehyde on telomere damage of somatic cells in mice. Methods Kunming mice were inoculated with different doses of formaldehyde (10, 20 and 40 mg / kg) for 7 consecutive days. The relative lengths of the telomere DNA repeat (OD260), hematocrit, . Results Compared with the control group, the telomerase reverse transcripts of blood cells, hepatocytes and renal cells in 10, 20 and 40 mg / kg groups were shortened significantly (P <0.05, P <0.01) Formaldehyde exposure dose showed a shortening trend. Conclusion Formaldehyde exposure can destroy the telomere stability in mice.