Objective: The aim of this study is to evaluate the effectiveness and safety of xiyanping injection?(XYPI) in the treatment of children with bronchopneumonia. Methods: A?systematic and comprehensive search was conducted in the domestic and foreign electronic databases CNKI, SinoMed, VIP, WanFang DATA, PubMed, The Cochrane Library, Embase, Web of Science, Clinical?Trials.gov, and the search date ended on May 30, 2019. Inclusion criteria:?(1) the types of studies included were randomized controlled trials;?(2) the study participants were infants and children with a clear diagnosis of bronchopneumonia, without gender and ethnic restrictions;?(3) the intervention test group was XYPI or the control group plus XYPI. The control group was routine treatment? (RT)? (basic treatment such as fever, cough and asthma, oxygen inhalation, anti?infection, maintaining water, electrolyte balance, etc.) or other Western medicine or RT?+?other Western medicine treatment. Except for XYPI, the two groups were consistent in intervention measures. According to the Cochrane Handbook, 5.1 evaluation standard and a meta?analysis of the final included studies was performed using RevMan 5.3 software. Results: A?total of 57 studies were included, with a total sample size of 8454?cases, of which 4255 were in the experimental group and 4199 were in the control group. Meta?analysis results showed that?(1) Total effective rate: XYPI group was better than the control group?(relative risk?[RRRT] = 1.25, 95％ confidence interval?[CI]?[1.15, 1.36], P?