本文介绍近年来用分离的泌酸细胞,研究组织胺、乙酰胆碱和胃泌素以及组织胺、前列腺素(PG)和环一磷酸腺苷(cAMP)在盐酸分泌过程中的作用及其相互关系的一些设想。(1)组织胺、乙酰胆碱和胃泌素均可直接与泌酸细胞上各自的受体相结合而引起盐酸分泌,它们之间有着相互加强的作用;(2)组织胺通过增加泌酸细胞内的cAMP促进酸的分泌;(3)PG从两个方面对胃粘膜产生保护作用,即对抗依赖于组织胺的cAMP形成和促进另一细胞系统内依赖于PG的cAMP的形成。 This article describes the role of histamine, acetylcholine and gastrin as well as histamine, prostaglandin (PG) and cAMP in the secretion of hydrochloric acid in secrete acid-secreting cells in recent years and their interrelations Some ideas. (1) histamine, acetylcholine and gastrin can be directly associated with the respective receptors on oxytocin cells to cause the secretion of hydrochloric acid, there is a mutual strengthening between them; (2) histamine by increasing acid secretion intracellular (3) PG protects the gastric mucosa in two aspects, namely against histamine-dependent cAMP formation and on PG-dependent cAMP formation in another cell system.