论文部分内容阅读
目的:研究XIAP在舌鳞癌组织中的表达情况及其与舌鳞癌临床病理特征的关系。方法:采用免疫组织化学SP法检测舌鳞癌组织(36例)以及癌旁正常舌粘膜组织(20例)中XIAP蛋白的表达,并分析其与舌鳞癌临床病理特征的关系。结果:XIAP在舌鳞癌组织中表达阳性率为86.1%,在癌旁正常粘膜组织中阳性率为35%,肿瘤组织中XIAP蛋白阳性率明显高于正常粘膜;不同病理分级及临床分期病例XIAP阳性表达差异无显著性。结论:XIAP蛋白的高表达与舌鳞癌的发生有相关性,可能在舌鳞癌的发生、发展过程中有重要作用。
Objective: To study the expression of XIAP in tongue squamous cell carcinoma and its relationship with clinicopathological features of tongue squamous cell carcinoma. Methods: The expression of XIAP protein in tongue squamous cell carcinoma (36 cases) and adjacent normal mucosa (20 cases) was detected by immunohistochemical SP method. The relationship between the expression of XIAP and clinicopathological features was analyzed. Results: The positive rate of XIAP expression in tongue squamous cell carcinoma was 86.1%, the positive rate in adjacent normal mucosa was 35%, and the positive rate of XIAP protein in tumor tissues was significantly higher than that in normal mucosa. The pathological grade and clinical stage XIAP The positive expression difference was not significant. Conclusion: The high expression of XIAP protein is associated with the occurrence of tongue squamous cell carcinoma, which may play an important role in the genesis and development of tongue squamous cell carcinoma.