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目的检测自然杀伤细胞(NK)在强直性脊柱炎(AS)外周血中的水平,探讨NK细胞与AS病情活动及其在功能评估中的意义。方法采用流式细胞技术检测30例未经治疗的活动期AS患者及30例健康对照人群外周血中NK细胞数量的变化。结果 AS患者NK细胞数量为(11.03±5.20)%,低于对照组(14.58±6.57)%,差异有统计学意义(P<0.05);AS患者外周血NK细胞水平与血沉、超敏C反应蛋白、AS功能指标BASFI和BASMI呈负相关(r=-0.556、-0.632、-0.833、-0.798,P<0.05)。结论AS患者外周血存在NK细胞数量减少,可作为评价疾病活动性和功能评估指标的一种参数指标。
Objective To detect the level of natural killer cells (NK) in the peripheral blood of ankylosing spondylitis (AS) and to explore the significance of NK cell and AS disease activity and its function evaluation. Methods Flow cytometry was used to detect the number of NK cells in 30 untreated active AS patients and 30 healthy controls. Results The number of NK cells in AS patients was (11.03 ± 5.20)%, lower than that in control group (14.58 ± 6.57)%, the difference was statistically significant (P <0.05) Protein and AS function index BASFI was negatively correlated with BASMI (r = -0.556, -0.632, -0.833, -0.798, P <0.05). Conclusion There is a decrease in the number of NK cells in peripheral blood of patients with AS, which can be used as a parameter index to evaluate disease activity and function evaluation index.