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研究选择冠心病稳定型心绞痛患者２６例，分别以８０μｇ／ｍｉｎ和１６０μｇ／ｍｉｎ的剂量静脉滴注硝酸异山梨酯（ＩＳＤＮ）３０分钟，经左心导管测定血液动力学参数。结果显示８０μｇ／ｍｉｎ组用药前后（１５分钟）仅左室舒张末压明显下降，而１６０μｇ／ｍｉｎ较大剂量组除发现左室舒张末压显著降低外，主动脉收缩压、主动脉平均压的降低也达到统计学意义，两组治疗前后的心率、主动脉舒张压、左室收缩压最大上升速度均无显著变化，提示１６０μｇ／ｍｉｎ较大剂量静滴ＩＳＤＮ不仅能降低容量负荷，还可使动脉系统压力下降。左心室灌注压升高，左室舒张末压和心容积减少、收缩期射血分布到室壁力量减弱均可降低心肌耗氧量，改善心肌缺血。
A total of 26 patients with stable angina pectoris were enrolled in this study. Isosorbide dinitrate (ISDN) was intravenously injected at a dose of 80 μg / min and 160 μg / min for 30 min, and hemodynamic parameters were measured by left cardiac catheterization. The results showed that left ventricular end-diastolic pressure decreased significantly in 80μg / min group (15 minutes), while in the higher dose of 160μg / min group, the left ventricular end-diastolic pressure was significantly decreased, the aortic systolic pressure, mean aortic pressure Reduce also reached statistical significance, heart rate before and after treatment in both groups, aortic diastolic blood pressure, maximum increase in systolic blood pressure did not change significantly, suggesting that larger doses of 160μg / min intravenous infusion of ISDN not only reduce the volume load, but also Arterial system pressure drops. Left ventricular perfusion pressure increased, left ventricular end-diastolic pressure and heart volume decreased systolic ejection distribution to the wall of the wall can reduce myocardial oxygen consumption, improve myocardial ischemia.