作者在57例健康儿童及25例不同程度缺铁的儿童中测定红细胞内游离原卟啉(FEP)和血清铁蛋白。发现FEP与血红蛋白浓度(γ=-0.80)和血清铁蛋白(γ=-0.64)呈负相关。血红蛋白低于12.5g/dl或血清铁蛋白低于8μg/L儿童的FEP增加。在一组显然血液学正常的10～14岁儿童中(血红蛋白>12.5g/dl),试用铁剂2个月结果血红蛋白及铁蛋白增加,而FEP减少,提示在铁剂治疗之前作为血红蛋白合成的铁供给是不足的。有一个缺铁患者(FEP15.3μmole/L,血红蛋白5.2g/dl),在铁治疗之后,血红蛋白、血清铁运铁蛋白饱和度和铁蛋白改变能被捡出之前,FEP已迅速下降。在缺铁治疗开始之时,FEP已迅速下降,从而使FEP成为缺铁性贫血体内铁运血停滞的一种生化敏感指标。虽然缺铁性贫血的通常指标即血红蛋白和血清运铁蛋白饱和度,已恢复到正常水平,但缺铁可能持续存在。于是,在生长期儿童,通常难以平衡铁需要和供给情况,在隐性前 The authors determined erythrocytic free protoporphyrin (FEP) and serum ferritin in 57 healthy children and 25 children with varying degrees of iron deficiency. FEP was found to be negatively correlated with hemoglobin concentration (γ = -0.80) and serum ferritin (γ = -0.64). FEP increases in children with hemoglobin below 12.5 g / dl or serum ferritin below 8 μg / L. In a group of apparently hematologically normal children aged 10-14 years (hemoglobin> 12.5 g / dl), iron supplementation for 2 months resulted in an increase in hemoglobin and ferritin, whereas a decrease in FEP suggested a synthesis of hemoglobin prior to iron treatment Iron supply is not enough. In an iron-deficient patient (FEP 15.3 μmole / L, hemoglobin 5.2 g / dl), FEP decreased rapidly after hemoglobin, serum iron transferrin saturation and ferritin changes could be detected after iron treatment. At the onset of iron-deficiency therapy, FEP has rapidly decreased, making FEP a biochemical-sensitive indicator of iron blockade in iron-deficiency anemia. Although the usual indicators of iron deficiency anemia, hemoglobin and serum transferrin saturation, have returned to normal levels, iron deficiency may persist. As a result, it is often difficult for children in growing age to balance iron demand and supply before recessive