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目的:探讨脾氨肽治疗儿童复发性口腔溃疡(ROU)的疗效及其对细胞免疫功能的影响。方法:将68例ROU患儿分为脾氨肽组35例和对照组33例。对照组患儿予以单纯的碘甘油局部外涂治疗,脾氨肽组在对照组治疗基础上予以口服脾氨肽冻干粉每次2 mg,隔日1次,凉开水溶解,连用3个月。结果:治疗3个月后,两组患儿CD4+水平和CD4+/CD8+较前均有上升(P<0.05),脾氨肽组上升值较对照组更明显(P<0.05),而两组患儿治疗前后CD8+水平变化不明显(P>0.05);脾氨肽组临床总有效率明显高于对照组(χ2=7.63,P<0.01),两组治疗期间均无明显的药物不良反应发生。结论:脾氨肽治疗儿童ROU的疗效肯定,安全性较好,可能与其纠正ROU外周血T淋巴细胞亚群功能紊乱,触发和增强儿童细胞免疫功能密切相关。
Objective: To investigate the therapeutic effect of splenic aminopeptidase on children with recurrent oral ulcer (ROU) and its effect on cellular immune function. Methods: 68 children with ROU were divided into 35 cases of splenomegaly peptide group and 33 cases of control group. The control group of children given pure topical iodine glycerol treatment, spleen ammonia peptide group in the control group on the basis of oral administration of spleen ammonia peptide lyophilized powder each 2 mg, every other day, cold water dissolved, once every 3 months. Results: The levels of CD4 + and CD4 + / CD8 + in both groups were significantly higher than those in the control group (P <0.05) after 3 months of treatment, but were higher in the splenomegaly group (P <0.05) There was no significant difference in the level of CD8 + between before and after treatment (P> 0.05). The total effective rate of spleen aminopeptidase group was significantly higher than that of control group (χ2 = 7.63, P <0.01). Conclusion: The therapeutic effect of splenic aminopeptidase on children with ROU is definite and safe, which may be closely related to correcting the dysfunction of T lymphocyte subsets in peripheral blood of ROU and triggering and enhancing cellular immune function in children.