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目的观察班氏丝虫微丝蚴血症者的持续时间、密度消长及传播作用。方法采用厚血膜法每年或每隔1~3年对微丝蚴血症者和监测点全寨人血检,用间接荧光抗体试验(IFAT)和丝虫特异IgG4试剂盒检测人群丝虫抗体水平,用快速酶联免疫试验(ICT)检测人群丝虫特异抗原,在传播季节解剖致倦库蚊,了解幼丝虫感染率、感染度及传播作用。结果在24年观察期间,11次全民血检,检出5例微丝蚴血症者,其中原微丝蚴血症者4例,新感染者1例。4例原微丝蚴血症者中,2例分别于第7年和第13年自然转阴;另外2例微丝蚴血症分别持续20年和24年,经用乙胺嗪治疗后转阴。结论个别微丝蚴血症者可持续24年以上,具有一定的传播作用,监测工作仍不能终止。
OBJECTIVE To observe the duration, density, growth and spread of filarial microfilaria in B. bancrofti and its transmission. Methods Thirty-seven patients with microfilaremia and monitoring point Quanzhai were examined by thick-membrane method every year or every 1-3 years. IFA and FIBA-specific IgG4 kit Level, using a rapid enzyme-linked immunosorbent assay (ICT) to detect filarial specific antigen in the population, dissecting Culex pipiens pallens in the seasons of transmission, and understanding the infection rate, infectivity and transmission of the young filariasis. Results During the 24-year observation period, 11 people were examined by universal blood tests, and 5 cases of microfilaremia were detected. Among them, 4 cases were original microfilaremia and 1 case was newly infected. 4 cases of original microfilaremia, 2 cases of natural negative in the 7th and 13th year; the other two cases of microfilaremia continued for 20 years and 24 years, after treatment with diethylcarbamazine yin. Conclusion Individual microfilariae laxatives can last for more than 24 years and have a certain spreading effect. Monitoring work can not be stopped yet.