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目的:分析复发性自然流产(RSA)妇女外周血调节性T细胞和辅助性T细胞表达的变化。方法:选择2009年10月～2010年7月住院确诊的RSA育龄期妇女21例(RSA组),入选对象均接受了外周血调节性T细胞(CD4+、CD25+、Treg和CD4+、CD25+、Foxp3+Treg)和辅助性T细胞(CD3+、CD4+、CD8+、CD4+/CD8+)检测,并与20例同期住院正常妊娠产妇(正常妊娠组)及20例未孕育龄妇女(对照组)测试结果比较。结果:调节性T细胞比较中,RSA组血清CD4+、CD25+、Treg和CD4+、CD25+、Foxp3+Treg水平明显低于正常妊娠组及对照组,有统计学差异(P<0.05或P<0.01);辅助性T细胞比较中,RSA组和正常妊娠组血清CD4+/CD8+表达水平明显高于对照组(P<0.05),而CD8+表达水平则显著低于对照组,差异有统计学意义(P<0.05或P<0.01)。结论:RSA患者存在明确的外周血调节性T细胞和辅助性T细胞异常表达。
Objective: To analyze the changes of the expression of regulatory T cells and helper T cells in peripheral blood of recurrent spontaneous abortion (RSA) women. Methods: A total of 21 RSA women of childbearing age who were hospitalized in our hospital from October 2009 to July 2010 were enrolled in this study. All the selected subjects received CD4 +, CD25 +, Treg and CD4 +, CD25 +, Foxp3 + Treg and T-helper T-cells, and compared with the results of 20 normal pregnant women (normal pregnancy group) and 20 non-pregnant women (control group). Results: The levels of CD4 +, CD25 +, Treg and CD4 +, CD25 + and Foxp3 + Treg in RSA group were significantly lower than those in normal pregnancy group and control group (P <0.05 or P <0.01). In the comparison of helper T cells, the level of CD4 + / CD8 + expression in RSA group and normal pregnancy group was significantly higher than that in control group (P <0.05), while the level of CD8 + expression in RSA group and normal pregnancy group was significantly lower than that in control group Or P <0.01). Conclusion: There is a clear abnormal expression of peripheral blood regulatory T cells and helper T cells in RSA patients.