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从免疫细胞功能调控因素初步探讨镉免疫毒性机理０．３－２．４ｍｇ／ｋｇ／ｄ氯化镉连续给小鼠灌胃１４ｄ，观察免疫器官重量及免疫功能、淋巴细胞内钙离子浓度、钙调素（ＣａＭ）含量、巨噬细胞内ＮＯ、Ｏ２－、Ｈ２Ｏ２变化。结果是０．３－２．４ｍｇ／ｋｇ／ｄ氯化镉对免疫器官重量未见有明显影响，但０．３ｍｇ／ｋｇ／ｄ组腹腔灌洗液巨噬细胞总数减少、体液免疫和巨噬细胞吞噬功能抑制，淋巴细胞胞内钙离于增加、钙调素呈下降趋势，巨噬细胞ＮＯ生成、Ｏ２－减少、Ｈ２Ｏ２有减少趋势体外试验５０μｍｏｌ／Ｌ氯化镉出现抑制淋巴细胞转化、ＩＬ－２减少、胞内钙离子增加、ＣａＭ含量降低趋势认为镉免疫毒性可能与其引起淋巴细胞钙稳态失衡密切相关
The mechanism of cadmium immunotoxicity was investigated preliminarily on the mechanism of immune cell function. Cadmium chloride 0.3-0.4mg / kg / d was given intragastrically to mice for 14 days. The weight of immune organ, immune function, calcium ion concentration in lymphocytes, The content of CaM, the changes of NO, O2- and H2O2 in macrophages. The results were 0.3-2.4mg / kg / d cadmium chloride on immune organ weight no significant effect, but 0.3mg / kg / d group peritoneal lavage fluid macrophage decreased the total number of humoral immunity and macrophage Cytosolic phagocytosis, lymphocyte intracellular calcium increased, calmodulin showed a downward trend, macrophage NO production, O2-reduced, H2O2 decreased trend in vitro experiments of 50μmol / L cadmium chloride inhibited lymphocyte transformation, IL -2 decreased, increased intracellular calcium, CaM content decreased trend that cadmium immunotoxicity may be closely related to its caused by the imbalance of calcium homeostasis