论文部分内容阅读
目的 研究复方黄黛片中砷在健康志愿者体内的药代动力学行为。方法 用ICP -MS测定健康志愿者血中砷的浓度 ,用 3P97处理药动学数据 ,SPSS进行统计分析。结果和结论 健康志愿者药动学参数分别为A =0 .30 6 0± 0 .0 90 9mg·L-1,Ke=0 .0 74 9± 0 .0 12 5 1/h ,Ka =0 .2 199± 0 .0 3471/h ,TLag =0 .0 72 4± 0 .0 6 2 1h ,T1/ 2 (Ka) =3.2 0 70± 0 .5 2 6 0h ,T1/ 2 (Ke) =9.2 6 6 2± 1.344 4h ,Tpeak =7.4 4 99± 0 .3184h ,Cmax =0 .10 75± 0 .0 0 31mg·L-1,AUC =2 .5 5 0 8± 0 .15 2 8mg·L·h-1,CL/F(s) =195 9.1970± 110 .182 2L·h-1,V/F(c) =2 6 2 35 .376 0± 2 731.4 15 8L。单剂量口服复方黄黛片后 ,72h内砷元素在体内呈一级吸收
Objective To study the pharmacokinetics of arsenic in compound Huangqi Tablets in healthy volunteers. Methods ICP-MS was used to determine the concentration of arsenic in blood of healthy volunteers. Pharmacokinetic data were processed with 3P97 and SPSS was used for statistical analysis. Results and conclusions The pharmacokinetic parameters of healthy volunteers were A=0.30 6 0±0.090 9mg·L-1, Ke=0.074 9±0. 0 12 5 1/h, and Ka=0. .2 199± 0 .0 3471/h, TLag =0.0 72 4± 0 . 0 6 2 1h, T1/ 2 (Ka) = 3.2 0 70± 0 .5 2 6 0h, T1/ 2 (Ke) =9.2 6 6 2 ± 1.344 4h, Tpeak =7.4 4 99 ± 0.318h, Cmax =0.10 75± 0 .0 0 31mg·L-1, AUC = 2 .5 5 0 8 ± 0 .15 2 8mg L·h-1, CL/F(s) = 195 9.1970 ± 110.182 2L·h-1, V/F(c) = 2 6 2 35 .376 0 ± 2 731.4 15 8L. After single-dose oral compound Huangqi tablets, arsenic levels were absorbed in the body within 72 hours.