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目的 探讨血小板活化因子 (PAF)受体拮抗剂海风藤新木脂素类成分对鼠脑梗死面积、局部脑血流量 (rCBF)及神经功能缺失征象的影响 ,并与传统的PAF受体拮抗剂银杏苦内酯相比较。方法 利用TTC染色结合球积仪、氢清除法组织血流计和临床神经功能评分标准等方法 ,分别对缺血、缺血再灌注及海风藤新木脂素类成分、银杏苦内酯治疗组鼠脑梗死面积、rCBF、神经功能缺失征象进行观察和比较。结果 海风藤新木脂素类成分、银杏苦内酯药物治疗组脑梗死面积较缺血再灌组明显减小 ,同时药物能改善缺血侧皮质rCBF的下降 ,并显著减轻脑缺血后的神经功能缺损。结论 海风藤新木脂素类成分与传统的PAF受体拮抗剂银杏苦内酯均具有显著的脑保护作用
Objective To investigate the influence of platelet activating factor (PAF) receptor antagonists, kaempferol lignans, on cerebral infarct size, regional cerebral blood flow (rCBF) and neurologic deficits in rats, and to compare with conventional PAF receptor antagonists. Ginkgo Biloba Lactones are compared. Methods TTC staining was used in combination with spherometer, hydrogen scavenging method for tissue flowmeter and clinical neurological function scoring criteria. They were applied to ischemia, ischemia reperfusion, and the components of marivariin and ginkgolides. The cerebral infarct size, rCBF, and neurological deficit signs were observed and compared. Results Compared with the ischemic reperfusion group, the infarct size of the sea vine oligosaccharides and the ginkgolide-treated group was significantly reduced. At the same time, the drug could improve the decrease of rCBF in the ischemic cortex and significantly reduced the post-cerebral ischemia. Neurological deficits. Conclusion The lignans of Kaempferolens and the traditional PAF receptor antagonist Ginkgolides have significant neuroprotective effect.