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目的本通过研究外周血PRL水平与T淋巴细胞亚群变化的相关性,以探讨泌乳素(PRL)与免疫系统变化的关系。方法检测100例垂体腺瘤患者及56例体检健康人外周血中CD4+CD25+、CD3+、CD3+CD4+及CD3+CD8+的T淋巴细胞水平;并测定其外周血中PRL水平。结果病例组外周血CD3+T淋巴细胞显著低于健康人组(P<0.0001);外周血CD3+CD4+T淋巴细胞及CD3+CD8+T淋巴细胞病例组与健康人组均无显著差异(P>0.05);病例组外周血CD4+CD25+T淋巴细胞为显著高于健康人组(P<0.0001)。其中病例组中PRL<100ng/ml组外周血CD3+T淋巴细胞及CD3+CD4+T淋巴细胞均显著低于PRL>100ng/ml组(P<0.05);外周血CD3+CD8+T淋巴细胞及CD4+CD25+T淋巴细胞,病例组与健康人组均无显著差异(P>0.05)。结论 CD3+T淋巴细胞的减少可能是垂体肿瘤细胞本身刺激CD4+CD25+T淋巴细胞的增生,导致外周血IL-2减少,从而抑制了T淋巴细胞的活化和增殖。外周血PRL>100ng/ml组外周血PRL显著升高,通过刺激各种细胞因子的分泌,而进一步促进T淋巴细胞的活化及增殖,同时,外周血中高PRL可直接抑制外周血T淋巴细胞的凋亡。
Objective To investigate the relationship between prolactin (PRL) and immune system by studying the correlation between peripheral blood PRL levels and T lymphocyte subsets. Methods The levels of CD4 + CD25 +, CD3 +, CD3 +, CD4 + and CD3 + CD8 + in peripheral blood of 100 pituitary adenoma patients and 56 healthy controls were measured. The levels of PRL in peripheral blood were measured. Results The CD3 + T lymphocytes in peripheral blood of patients were significantly lower than those of healthy controls (P <0.0001). There were no significant differences in CD3 + CD4 + T lymphocytes and CD3 + CD8 + T lymphocytes between healthy controls and healthy controls P> 0.05). CD4 + CD25 + T lymphocytes in the peripheral blood of the patients were significantly higher than those in healthy controls (P <0.0001). In the case group, the levels of CD3 + T lymphocytes and CD3 + CD4 + T lymphocytes in PRL <100ng / ml group were significantly lower than those in PRL> 100ng / ml group (P <0.05); CD3 + CD8 + T lymphocytes And CD4 + CD25 + T lymphocytes, there was no significant difference between case group and healthy group (P> 0.05). Conclusion The decrease of CD3 + T lymphocytes may be the result of pituitary tumor cells stimulating the proliferation of CD4 + CD25 + T lymphocytes, leading to the decrease of IL-2 in peripheral blood and inhibiting the activation and proliferation of T lymphocytes. Peripheral blood PRL> 100ng / ml group of peripheral blood PRL was significantly increased by stimulating the secretion of various cytokines, and further promote T lymphocyte activation and proliferation, while the high peripheral blood PRL can directly inhibit peripheral blood T lymphocytes Apoptosis.