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R叩er氏和Olson氏报道:家兔对蕙环类抗肿瘤抗生素敏感,能产生与人类相类似的心肌病理变化,是一种研究葱环类药物心脏毒性的理想动物模型。 本文以家兔为实验动物模型,研究柔红霉素(DNR)、阿霉素(ADM)和阿克拉霉素-B(ACM一B)三种药的急性心脏毒性。 近十多年来对心脏收缩时间间?
R knocker and Olson’s report: Rabbits are sensitive to the antibacterial agents of the loop type antitumor antibiotics, and can produce pathological changes of myocardium similar to human beings. It is an ideal animal model for studying the cardiotoxicity of onion rings drugs. In this paper, rabbits were used as experimental animal models to study the acute cardiotoxicity of three drugs daunorubicin (DNR), doxorubicin (ADM) and aclacinomycin-B (ACM-B). Nearly a decade of systolic time?