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应用免疫组织化学方法，研究105例乳腺癌手术标本中bcl-2基因的表达情况，探讨其临床病理学意义。同时进行雌二醇测定，研究其与bcl-2基因的关系。结果显示；乳腺癌中bcl-2基因的表达率为48．6％，bcl-2表达与乳腺癌临床病理分期及肿瘤大小呈负相关（P分别＜O．005、0．05），而与肿瘤细胞分化程度呈正相关（P＜O．05）。bcl-2阳性患者术后3年、5年生存率明显高于阴性组（P＜0.05）。此外，bcl-2基因表达与雌二醇密切正相关（P＜O.001）。我们认为，bcl-2基因在乳腺癌中的表达与激素调节有关，并参与乳腺癌生物学行为的调控。
Immunohistochemical method was used to study the expression of bcl-2 gene in 105 breast cancer surgical specimens and explore its clinical pathological significance. Estradiol was measured at the same time to study its relationship with bcl-2 gene. The results showed that the expression rate of bcl-2 gene in breast cancer was 48.6%. The expression of bcl-2 was negatively correlated with clinical stage and tumor size of breast cancer (P<0.05). The degree of differentiation of tumor cells was positively correlated (P < 0.05). The 3-year and 5-year survival rates of bcl-2 positive patients were significantly higher than those of negative patients (P<0.05). In addition, bcl-2 gene expression was positively correlated with estradiol (P < O.001). We believe that the expression of bcl-2 gene in breast cancer is related to hormone regulation and involved in the regulation of biological behavior of breast cancer.