给兔按每日每公斤体重喂饲50mg 和100mg 氟化钠,7个月后处死,对其肝、肾、甲状腺和心肌作透式电镜观察。四种器官之主要细胞的超微结构观察发现线粒体肿胀,崤局部或全部消失,以肾脏近曲小管、肾小囊之足细胞最为严重,甲状腺上皮细胞,肝细胞次之,心肌细胞未见异常。讨论了这些改变的意义。 The rabbits were fed 50 mg and 100 mg sodium fluoride per kilogram of body weight per day. They were sacrificed 7 months later and their liver, kidney, thyroid and myocardium were examined under transmission electron microscope. Ultrastructural observations of the main cells of the four organs revealed that the mitochondria were swollen and the sputum partially or completely disappeared. The podocytes in the renal proximal tubules and renal cysts were the most severe, and the thyroid epithelial cells followed by the hepatocytes. No abnormalities were observed in the myocytes. . Discuss the significance of these changes.