肝癌侵袭转移是一个涉及多基因、多步骤复杂的病理过程,包括原发癌细胞脱落,基质降解、间质浸润,组织特异趋化,血管侵入、转运,癌细胞捕获、逸出,靶器官选择,转移部位继发生长增殖等主要病理环节。细胞外基质是肿瘤细胞侵袭转移过程中面临的第一道屏障,脱落癌细胞与细胞外基质蛋白的黏附及其运动是侵袭转移始动环节早期事件[1],以往肝癌侵袭转移研究 Invasion and metastasis of liver cancer is a multi-gene, multi-step complex pathological processes, including the primary cancer cell shedding, matrix degradation, interstitial infiltration, tissue chemotaxis, vascular invasion, transport, cancer cell capture, escape, target organ selection , Metastasis secondary growth and proliferation of other major pathological links. Extracellular matrix is ​​the first barrier in invasion and metastasis of tumor cells. The adhesion of exfoliated cancer cells to extracellular matrix proteins and their movement are the early events of invasion and metastasis [1]. In the past, the invasion and metastasis of hepatocellular carcinoma