对8例心力衰竭患者静注国产氨力农1mg/kg,继以7.5μg/(kg·min)静滴6h。由漂浮导管测定血流动力学变化,HPLC法测血药浓度的改变。结果:心指数在血药浓度为1.05μg/mL左右时增加较大(最大增幅为23.8％),但不随浓度的继续上升而增高,两者有一定相关性(r=0.72,P<0.05)。肺动脉压和肺楔嵌压显著下降,但与血药浓度变化无关。提示该药的扩血管作用较明显,但可能存在耐受性。 Eight patients with heart failure intravenous injection of amrinone 1mg / kg, followed by intravenous infusion of 7.5μg / (kg · min) for 6h. The hemodynamic changes were measured by floating catheter, and the changes of blood concentration were measured by HPLC. Results: The cardiac index increased significantly when the plasma concentration was 1.05μg / mL (maximum increase was 23.8%), but did not increase with the increase of concentration (r = 0.72, P <0.05) . Pulmonary arterial pressure and pulmonary wedge pressure decreased significantly, but not with plasma concentration changes. Prompt vasodilator effect of the drug more obvious, but there may be tolerance.