论文部分内容阅读
目的:阐述钙离子与钙网织蛋白对心肌细胞的作用。资料来源:检索PubMed 1994-01/2005-12与钙离子和钙网织蛋白对心肌细胞作用的相关文章,检索词为“Ca2+,calreticulin,cardiomy-ocytes/cardiac myocyte,differentiation”,并限定语言种类为英语。资料选择:对所检索到的文献进行初筛,选择与钙离子和钙网织蛋白对心肌细胞作用的相关文章,筛除明显不符合原文的文章和重复性研究。资料提炼:共收集相关文章200篇,纳入42篇,排除158篇。资料综合:通过对内质网和肌质网上细胞内Ca2+释放通道(RyR和IP3R)的分子结构以及crt基因结构的研究表明:通道分子和钙网织蛋白共同参与调控体内Ca2+稳态,从而在心脏发育分化过程中发挥重要作用。结论:在心脏中细胞内游离Ca2+是一种关键的第二信使,细胞内Ca2+稳态的改变会显著影响许多心脏功能包括收缩舒张和心脏发育。细胞内Ca2+稳态的维持主要依赖内质网。在内质网中,钙离子主要与钙网织蛋白结合。crt基因敲除可损伤心脏发育而导致胚胎死亡。
Objective: To elucidate the effect of calcium ion and calcium reticulin on cardiomyocytes. Source: To search for articles related to the effects of calcium and calcium on cardiomyocytes from January 1994 to December 2005 with the search term of “Ca2 +, calreticulin, cardiomy-ocytes / cardiac myocyte, differentiation” English. Data selection: The retrieved documents were screened, and the articles related to the effects of calcium ion and calcium reticulin on cardiomyocytes were selected, and the articles that were obviously not consistent with the original text were screened out and the repetitive studies were screened out. DATA EXTRACTION: A total of 200 related articles were collected, including 42 articles and 158 articles excluded. DATA SYNTHESIS: The molecular structure of intracellular Ca2 + release channels (RyR and IP3R) and the structure of crt gene in endoplasmic reticulum and sarcoplasmic reticulum are studied. The results show that the channel molecule and calcium reticulum protein participate in the regulation of Ca2 + homeostasis, Cardiac development plays an important role in the process of differentiation. CONCLUSIONS: Intracellular free Ca2 + is a key second messenger in the heart. Changes in intracellular Ca2 + homeostasis can significantly affect many cardiac functions including systolic and diastolic and cardiac development. The maintenance of intracellular Ca2 + homeostasis relies mainly on the endoplasmic reticulum. In the endoplasmic reticulum, calcium ions mainly bind to calreticulin. crt knockout can damage heart development and lead to embryonic death.