经粘膜途径接种的抗原的免疫原性通常弱于全身途径接种,因此粘膜抗原接种后需要粘膜佐剂以获得有效水平的免疫应答。已知五聚体形式的霍乱毒素B亚单位( CTB)是有效的粘膜佐剂,当经粘膜途径与抗原一起给予时能增强抗原特异性分泌性Ig A( SIg A)应答,但口服CTB会被粘膜局部的酶和 The immunogenicity of the transmucosal inoculated antigen is generally weaker than that of the systemic route of inoculation, and mucosal adjuvants are required after vaccination of the mucosal antigen to achieve an effective level of immune response. The pentameric form of cholera toxin B subunit (CTB) is known to be a potent mucosal adjuvant that enhances the antigen-specific secreted IgA (SIgA) response when administered transmucosally with an antigen, but oral CTB will Local mucosal enzymes and