1972年以来我组对硝喹(2、4二氨基-6-[(3、4二氯苄基)亚硝基胺基]喹唑啉醋酸盐,简称679)作用于疟原虫红细胞内期和组织期进行了一系列的研究,发现服药后6小时即使鸡疟原虫组织期发生明显的形态变化(脑组织涂片),此后又在恒河猴实验发现该药能抑制食蟹猴疟原虫组织期的发育,肝脏的原虫数较对照组明显减少,形态亦有显著改变。本 Since 1972, our group on the quinolone (2,4-diamino-6 - [(3,4-dichlorobenzyl) nitrosamino] quinazoline acetate, referred to as 679) And tissue period conducted a series of studies found that even 6 hours after taking the drug even if the chicken Plasmodium period obvious morphological changes (brain tissue smear), and later in the rhesus monkey experiment found that the drug can inhibit cynomolgus malaria parasite During the development of the tissue, the number of protozoa in the liver was significantly reduced compared with the control group, and the morphology was also significantly changed. this