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目的探讨促纤维增生性恶性黑色素瘤(DM)的临床病理特征及生物学行为。方法收集1996年至2004年间行广泛切除的8例DM患者,对其临床及病理资料进行分析。结果DM多位于头颈部,平均Breslow厚度为2.2 mm,所有病例未见淋巴结转移。平均随访43.2月,2例复发(1例全身转移),其中1例死亡,1例带瘤存活。结论DM具有独特的临床和病理特征,生物学行为惰性,长期随访表明其淋巴结转移率极低,病理上要与多种肉瘤及癌相鉴别,免疫组化染色有助于鉴别论断。
Objective To investigate the clinicopathological characteristics and biological behavior of fibromic hyperplastic malignant melanoma (DM). Methods Eight DM patients with extensive resection between 1996 and 2004 were collected and their clinical and pathological data were analyzed. Results DM was mostly located in the head and neck with an average Breslow thickness of 2.2 mm. No lymph node metastases were found in all cases. After a mean follow-up of 43.2 months, two patients relapsed (one patient had systemic metastasis), of which one died and one patient survived. Conclusion DM has a unique clinical and pathological features, biological behavior is inert, long-term follow-up showed that the lymph node metastasis rate is very low, the pathological distinction with a variety of sarcomas and carcinomas, immunohistochemical staining contribute to the differential diagnosis.