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以尼莫地平为模型药物,聚乳酸(PLA)为载体材料,采用溶剂蒸发萃取法制备了N-乙烯基吡咯烷酮(NVP)接枝聚乳酸共聚物(PLA-g-PVP)微球,考察了聚乳酸质量分数、乳化剂质量分数、转速和投药质量比对微球的影响。采用红外光谱、差式扫描量热分析表征药物与载体的相互作用,扫描电镜观察微球表面形态,对不同接枝率共聚物微球的粒径、载药量、包封率及体外释放性能进行研究。结果表明,当w(PLA)=4%,w(乳化剂)=3%,转速9 000 r/min,投药质量比为2∶3时,不同接枝率改性聚乳酸微球形态圆整,平均粒径小于10μm,粒径分布窄,微球可连续释放14 d以上,释放速率随着接枝率增大而增大。
Nimodipine was used as model drug and polylactic acid (PLA) was used as the carrier material. N-vinylpyrrolidone (NVP) grafted polylactic acid copolymer (PLA-g-PVP) microspheres were prepared by solvent evaporation method. Effect of polylactic acid mass fraction, mass fraction of emulsifier, rotational speed and mass ratio on microspheres. The interaction between drug and carrier was characterized by infrared spectroscopy and differential scanning calorimetry. The surface morphology of microspheres was observed by scanning electron microscopy. The particle size, drug loading, entrapment efficiency and in vitro release of copolymer microspheres with different graft ratio research. The results showed that the morphology of poly (D, L-lactide-co-glycolide) beads with different graft ratio was round when the mass ratio of PLA to PLA was 4%, the emulsifier was 3%, the speed was 9 000 r / , The average particle size is less than 10μm, the particle size distribution is narrow, the microspheres can be released continuously for more than 14 days, and the release rate increases with the grafting rate.