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透明质酸(Hyaluronic Acid,HA)是糖胺多糖中的一种,后者是细胞的间质成分之一。1934年Meger和Palmer等发现HA并阐述其基本结构。以后的研究进一步证明,HA是肺间质中糖胺多糖最主要的成分。随着利用HA特异结合的透明质酸结合蛋白微量HA检测法的建立。近年来对HA在肺间质性疾病(interstitia1 lung disease,ILD)的支气管肺泡灌洗液(bronchoalveolar lavage们uid,BALF)浓度进行了测定,认为HA是反映肺间质疾病有实用价值的新指标,现将有关文献综述如下: 一、HA的生化及代谢 HA是由β-D-葡萄糖醛酸和2-乙酰氨基-2去氧-D葡萄糖分别以β_(1、3)β_(1、4)糖苷键连接而
Hyaluronic acid (HA) is one of the glycosaminoglycans, which is one of the interstitial components of cells. In 1934, Meger and Palmer discovered HA and explained its basic structure. Subsequent studies further prove that HA is the most important component of glycosaminoglycans in interstitial lung. Establishment of a micro HA assay with hyaluronan-binding protein that utilizes HA-specific binding. In recent years, the concentration of HA in bronchoalveolar lavage fluid (BALF) in interstitial lung disease (ILD) has been measured and HA is considered as a new index reflecting the practical value of interstitial lung disease , The relevant literature is summarized as follows: First, the biochemical and metabolic HA HA is β-D-glucuronic acid and 2-acetamido-2 deoxy-D glucose were β_ (1,3) β_ (1,4 ) Glycosidic bond