This paper presents a model-based approximate λ-policy iteration approach using temporal differences for optimizing paths online for a pursuit-evasion problem,where an agent must visit several target positions within a region of interest while simultaneously avoiding one or more actively pursuing adversaries.This method is relevant to applications,such as robotic path planning,mobile-sensor applications,and path exposure.The methodology described utilizes cell decomposition to construct a decision tree and implements a temporal difference-based approximate λ-policy iteration to combine online learning with prior knowledge through modeling to achieve the objectives of minimizing the risk of being caught by an adversary and maximizing a reward associated with visiting target locations.Online learning and frequent decision tree updates allow the algorithm to quickly adapt to unexpected movements by the adversaries or dynamic environments.The approach is illustrated through a modified version of the video game Ms.Pac-Man,which is shown to be a benchmark example of the pursuit-evasion problem.The results show that the approach presented in this paper outperforms several other methods as well as most human players. This paper presents a model-based approximate λ-policy iteration approach using temporal differences for optimizing paths online for a pursuit-evasion problem, where an agent must visit several target places within a region of interest while simultaneously avoiding one or more aggressive pursuing adversaries. This method is relevant to applications, such as robotic path planning, mobile-sensor applications, and path exposure. The method described in cell decomposition to construct a decision tree and implements a temporal difference-based approximate λ-policy iteration to combine online learning with prior knowledge through modeling to achieve the objective of minimizing the risk of being caught by an adversary and maximizing a reward associated with visiting target locations. Online learning and frequent decision tree updates allow the algorithm to quickly adapt to unexpected movements by the adversaries or dynamic environments The approach is illustrated through a modified ve rsion of the video game Ms.Pac-Man, which is shown to be a benchmark example of the pursuit-evasion problem.The results show that the approach presented in this paper outperforms several other methods as well as most human players.