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目的分析无创正压通气联合氨茶碱治疗慢性阻塞性肺疾病(COPD)合并呼吸衰竭的疗效。方法 88例慢性阻塞性肺疾病合并呼吸衰竭患者,运用计算机随机分组的方式分为对照组和观察组,各44例,对照组患者给予无创正压通气治疗,观察组患者则给予无创正压通气联合氨茶碱治疗,比较两组患者临床疗效和不良反应发生情况。结果治疗前,两组患者各肺功能指标(第一秒用力呼气容积占用力肺活量百分比、残气量/肺总量比值和肺一氧化碳弥散量)和动脉血气结果 (p H、动脉血气血氧分压、二氧化碳分压和血氧饱和度)差异无统计学意义(P>0.05),治疗后,观察组患者残气量/肺总量比值和肺一氧化碳弥散量和动脉血气结果明显优于对照组患者,差异有统计学意义(P<0.05),而两组患者第一秒用力呼气容积占用力肺活量百分比差异无统计学意义(P>0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论无创正压通气联合氨茶碱治疗慢性阻塞性肺疾病合并呼吸衰竭临床疗效肯定,优于单用无创正压通气,具有安全高效和不良反应少等特点,值得在临床上进一步推广应用。
Objective To analyze the curative effect of non-invasive positive pressure ventilation combined with aminophylline in the treatment of chronic obstructive pulmonary disease (COPD) complicated with respiratory failure. Methods A total of 88 chronic obstructive pulmonary disease patients with respiratory failure were randomly divided into control group and observation group, 44 cases in each group. Patients in control group received noninvasive positive pressure ventilation while patients in observation group received noninvasive positive pressure ventilation Combined with aminophylline treatment, the clinical efficacy and adverse reactions were compared between the two groups. Results Before treatment, the pulmonary function parameters (forced vital capacity exponent of vital capacity, residual capacity / total lung capacity and carbon monoxide dispersion) and arterial blood gas results (p H, arterial blood oxygen (P> 0.05). After treatment, the residual volume / total lung volume ratio, carbon monoxide diffusion volume and arterial blood gas level in the observation group were significantly better than those in the control group , The difference was statistically significant (P <0.05), while the two groups of patients forced expiratory volume occupancy force lung volume percentage difference was not statistically significant (P> 0.05). The incidence of adverse reactions in the two groups, the difference was not statistically significant (P> 0.05). Conclusion Noninvasive positive pressure ventilation combined with aminophylline in the treatment of chronic obstructive pulmonary disease combined with respiratory failure, clinical efficacy is better than single noninvasive positive pressure ventilation, with safe and efficient and less adverse reactions, it is worth further clinical application.