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目的:观察抗炎明目汤治疗慢性葡萄膜炎的效果及其对免疫功能的调节作用。方法:95例(140只眼)患者接受了抗炎明目汤的治疗。治疗期间有的患者局部应用了皮质类固醇。其中对30例患者在治疗前后测定了体内IgA、IgG、IgM、循环免疫复合物、玫瑰花结形成试验和淋巴细胞转化试验。对小鼠在灌服抗炎明目汤治疗前后的T淋巴细胞亚群及T淋巴细胞转化试验进行了检测。结果:95例(140只眼)中116只眼(828%)治愈;24只眼(172%)视力提高4行以上。与治疗前相比,患者的细胞免疫和体液免疫功能均有明显改善(P<001)。结论:抗炎明目汤对慢性葡萄膜炎有治疗作用,并可双向调节免疫功能。
Objective: To observe the effect of anti-inflammatory Mingmu Decoction on chronic uveitis and its regulation on immune function. Methods: Ninety-five (140 eyes) patients received anti-inflammatory Mingmu Decoction. Some patients treated during the topical corticosteroid. Thirty patients were tested for IgA, IgG, IgM, circulating immune complex, rosette formation test and lymphocyte transformation test before and after treatment. T lymphocyte subsets and T lymphocyte transformation test in mice before and after treatment with anti-inflammatory Mingmu decoction were tested. Results: Of the 95 eyes (140 eyes), 116 eyes (82.8%) were cured. The visual acuity of 24 eyes (172%) was improved more than 4 lines. Compared with before treatment, patients with cellular immunity and humoral immune function were significantly improved (P <0 01). Conclusion: Anti-inflammatory Mingmu Decoction has a therapeutic effect on chronic uveitis and can regulate immune function bidirectionally.