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背景:新生儿缺氧缺血性脑病是较常见的新生儿疾病,可引起脑瘫、智力低下和惊厥。目前,该病常用的检查方法有CT扫描、MRI成像及单光子发射型计算机体层摄影等方法。目的:探讨新生儿缺氧缺血性脑病单光子发射型计算机体层摄影显像的特征,并与CT扫描、MRI成像进行比较,为新生儿缺氧缺血性脑病患儿的功能监测和早期干预提供理论基础。设计:以缺氧缺血性脑病患儿为研究对象,正常新生儿为对照组的观察对比研究。单位:一所大学医院的核医学科。对象:选择1998-09/2000-10在济宁医学院附属医院儿科住院的新生儿30例作为观察组,男23例,女7例;并随机选择同期10例正常新生儿为对照组,男7例,女3例。方法:对两组对象进行单光子发射型计算机体层摄影脑血流灌注显像,并与其CT、MRI结果进行对比。主要观察指标:①缺氧缺血性脑病患儿和新生儿单光子发射型计算机体层摄影脑血流显像特征比较;②单光子发射型计算机体层摄影脑血流灌注显像与CT和MRI检查的对比。结果:22例同时做单光子发射型计算机体层摄影、CT和MRI的患儿中,轻度组7例,单光子发射型计算机体层摄影、CT和MRI阳性数分别为7,3和5例;中度组10例中,3种方法的阳性数分别为10,8和9例;重度组5例,3种方法均为阳性;单光子发射型计算机体层摄影、CT和MRI总的阳性检出率分
Background: Neonatal hypoxic-ischemic encephalopathy is a more common neonatal disease that causes cerebral palsy, mental retardation and convulsions. Currently, the disease commonly used methods of examination are CT scan, MRI imaging and single photon emission computed tomography and other methods. OBJECTIVE: To investigate the characteristics of single photon emission computed tomography in neonatal hypoxic-ischemic encephalopathy and to compare the results with CT and MRI imaging in early neonatal hypoxic-ischemic encephalopathy Intervention provides the theoretical basis. Design: Children with hypoxic-ischemic encephalopathy as the research object, the normal newborn as a control group observed comparative study. Unit: a university hospital nuclear medicine. PARTICIPANTS: Thirty newborns hospitalized in the Pediatrics Department of Jining Medical College Affiliated Hospital from September 1998 to October 2000 were selected as the observation group. There were 23 males and 7 females. Ten normal neonates at the same period were selected as the control group. Male 7 Cases, female 3 cases. Methods: Single photon emission computed tomography cerebral perfusion imaging was performed on two groups of subjects, and compared with CT and MRI results. MAIN OUTCOME MEASURES: ①Comparison of single photon emission computerized tomography cerebral perfusion imaging in children with neonatal hypoxic-ischemic encephalopathy; ②Comparison between CT perfusion imaging and single-photon emission computed tomography Comparison of MRI examination. Results: Twenty-two patients who underwent single photon emission computed tomography at the same time were included in the study. Among the children with CT and MRI, 7 were mild and 7 were single-photon emission computed tomography. The positive numbers of CT and MRI were 7, 3 and 5 In the moderate group, the positive numbers of the three methods were 10, 8, and 9, respectively. In the severe group, 5 were positive and 3 were positive. The single photon emission computed tomography, CT and MRI Positive detection rate points