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目的:评价幽门螺杆菌(HP)相关性胃炎血清胃泌素测定的意义。方法:对慢性胃炎的HP感染的106例不同时间空腹血清胃泌素测定分为4组进行比较。结果:当HP感染仅限于胃粘膜内的血中抗HP抗体还没产生时,胃泌素的释放轻度增加(P<0.05),若HP感染不仅在胃粘膜中,而血中产生抗HP抗体后,胃泌素的释放明显增加(P<0.01)。当HP在胃粘膜已清除,血中虽有抗HP抗体存在,但胃泌素释放基本不受影响(P>0.05)。。结论:只要在胃粘膜中发现HP感染,使胃泌素释放增加,需要进行抗HP治疗,若仅血中查出抗HP抗体,而胃粘膜中未发现HP感染此时可不需治疗。
Objective: To evaluate the significance of serum gastrin in Helicobacter pylori related gastritis. Methods: A total of 106 patients with chronic gastritis HP infection at different times of fasting serum gastrin were divided into four groups for comparison. Results: When HP infection was limited to gastric mucosa in the blood of anti-HP antibody has not produced, gastrin release increased slightly (P <0.05), if HP infection not only in the gastric mucosa, and blood generated After anti-HP antibody, gastrin release increased significantly (P <0.01). When HP in the gastric mucosa has been cleared, despite the presence of anti-HP antibody in the blood, but gas release was basically not affected (P> 0.05). . CONCLUSIONS: Anti-HP treatment was required as long as HP infection was found in gastric mucosa and gastrin was released. Anti-HP antibodies were only found in blood and no HP infection was found in gastric mucosa at this time.