皮肤外用药以前多用于局部皮肤的治疗,七十年代后提出“药物治疗最佳化”,结合药品的物理特性、作用方法、体内动态及适用条件等进行“药物传递系统”(DDS)的研究,试图经皮肤途径治疗全身。具有代表性的“经皮吸收治疗系统”(TTS)有东莨菪碱、硝酸甘油、硝异梨醇等,雌二醇贴剂(商品名称Estraderm)在美国已用于 Previously, topical dermatological drugs were used for the treatment of topical skin. After the 1970s, “optimal drug treatment” was proposed, and “drug delivery system” (DDS) was studied in combination with the physical characteristics, action method, in vivo dynamics and applicable conditions of the drug , Trying to transdermal approach to the body. Representative “Percutaneous Absorption Therapy System” (TTS) scopolamine, nitroglycerin, such as nitrendiol, estradiol patch (trade name Estraderm) has been used in the United States