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慢性乙型病毒性肝炎(CHB)的发生机理相当复杂,越来越多的研究证实,机体的免疫功能紊乱,尤其是T淋巴细胞亚群与慢性肝病的发生发展密切相关。而CHB患者细胞免疫状态可影响干扰素的疗效。本文就CHB患者血清CD_4~+、CD_8~+ T细胞及CD_4~+/CD_8~+水平的变化与干扰素的疗效做一综述。
Chronic hepatitis B (CHB) mechanism of occurrence is quite complex, more and more studies have confirmed that the body’s immune dysfunction, especially T lymphocyte subsets and the occurrence and development of chronic liver disease are closely related. The cellular immune status of patients with CHB can affect the efficacy of interferon. This article reviews the changes of serum levels of CD_4 ~ +, CD_8 ~ + T cells and CD_4 ~ + / CD_8 ~ + in patients with CHB and the efficacy of interferon.