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利凡诺为一有效的中期引产药,但对其作用机制,迄无定论。本实验采用放射免疫测定技术,观察了10例孕妇在给利凡诺前、给药后10～15小时、宫缩开始时和流产前羊水中前列腺素水平的动态变化,其中PGE分别为213±54,553±138,968±243和1475±869(pg/ml);PGF_(2a)分别为369±104,392±167,1582±548和6006±2131(pg/ml)。结果表明,利凡诺引产的发动和进展,可能与内源性前列腺素的合成和释放增加有关。
Rivanol as a valid mid-term induction of labor, but its mechanism of action, as inconclusive. In this study, we used radioimmunoassay to observe the dynamic changes of prostaglandin levels in amniotic fluid of 10 pregnant women before amiodarone 10 to 15 hours after administration, at the beginning of uterine contractions and before amniotic fluid, in which PGE was 213 ± 54,553 ± 138,968 ± 243 and 1475 ± 869 (pg / ml); PGF_ (2a) were 369 ± 104,392 ± 167,1582 ± 548 and 6006 ± 2131 (pg / ml), respectively. The results show that the initiation and progress of rivanol induced labor may be related to the increased synthesis and release of endogenous prostaglandins.