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本实验观察生脉注射液对豚鼠Ouabain LD_(100)、致室性纤维颤动、室性心动过速剂量的影响。预先给生脉注射液0.1ml/100g体重Ⅳ(相当于生药0.0415g),5分钟后静脉恒速灌注0.025％Ouabajn,测得Ouabain LD_(100)剂量为0.4mg/kg体重(P<0.01),致室颤剂量为0.29mg/kg体重(P<0.01),致室性心动过速剂量为0.28mg/kg体重(P<0.01)。预先给单方五味子和人参根提取液各为20mg/100g体重(生药)Ⅳ,其Ouabain LD_(100)为0.43mg/kg(P<0.01)和0.34mg/kg(P<0.05)。生脉注射液、五味子提取液、人参根提取液对豚鼠Ouabain LD_(100)剂量都有增加作用,与对照组比较有非常显著和显著意义。生脉注射液还增加Ouabain致室颤和室性心动过速剂量,与对照组比较有非常显著的意义。结果提示,生脉注射液对强心甙的心脏毒性有保护作用。
This experiment was conducted to observe the effect of Shengmai Injection on the dose of ouabain LD_(100), ventricular fibrillation, and ventricular tachycardia in guinea pigs. Give Shengmai injection 0.1ml/100g body weight IV (equivalent to crude drug 0.0415g), and administer 0.025% Ouabajn at a constant rate after 5 minutes. The Ouabain LD 100 dose was 0.4mg/kg body weight (P<0.01). The dose of ventricular fibrillation was 0.29 mg/kg body weight (P<0.01), and the dose of ventricular tachycardia induced was 0.28 mg/kg body weight (P<0.01). The schisandra and ginseng root extracts were preliminarily given 20 mg/100 g body weight (crude drug) IV, and the Ouabain LD 100 was 0.43 mg/kg (P<0.01) and 0.34 mg/kg (P<0.05). Shengmai injection, Schisandra extract, and ginseng root extract all increased the dose of Ouabain LD 100 in guinea pigs, which was very significant and significant compared with the control group. Shengmai injection also increased Ouabain-induced ventricular fibrillation and ventricular tachycardia dose, compared with the control group has a very significant significance. The results suggest that Shengmai Injection has a protective effect on cardiotoxicity of cardiac palsy.